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Editor’s pick Health

Fiber Supplement for Knee Osteoarthritis Pain: What the Inulin Trial Found

  • In the UK INSPIRE trial (Nutrients, February 2026), 117 adults with knee osteoarthritis took 20 g a day of inulin, a prebiotic fiber found in chicory root, did an app-based exercise program, did both, or took a placebo powder for 6 weeks.
  • Compared with placebo, knee pain fell by 1.11 points on a 0–10 scale with inulin, 1.55 with exercise and 1.67 with both. Inulin also improved grip strength by about 4.6 kg (10 lb), while exercise improved standing and walking tests.
  • The trial was small and short, randomization was changed partway through, and the inulin pain result was borderline (95% CI −2.18 to −0.04). A blinded US trial at Yale is listed with an estimated start of November 2026.
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